Vegetation control may also be employed to reduce the habitat and wind protected cover that is created by plants for both adult and immature vectors. This control methodology is carefully planned and coordinated with Federal and State regulatory agencies, such as the U.S. Fish and Wildlife Service, the U.S. Army Corps of Engineers, and the California Department of Fish and Game, when working in sensitive habitats or in proximity to threatened or endangered species to assure the minimization of any impact to protected species or habitats. This work is usually accomplished with hand tools or with heavy equipment, depending on the size of the project.

Vegetation control can also be accomplished with the use of herbicides. These materials are used under strict guidelines that make sure they are applied properly to sites that will not impact other habitats. The district does not use herbicides in its program at this time.